St. James’s Hospital in Dublin, Ireland is at the forefront of RFID adoption in hospitals worldwide. Over the last two decades, St. James’s Hospital has both established RFID as outlined in GS1 standards as a driver of clinical innovation as well as a pillar for information-based management. Alan Buckley will outline how RFID became a tool of transformation, sharing the basics used to reproduce earlier successes and avoiding known caveats. A set of tools and benefits worth applying in any line of business where traceability has a strategic impact.